For people at risk of heart disease,
cholesterol-lowering statins were once thought to
be a miracle drug — a "catchall" medicine that
could prevent strokes, heart attacks and even
Alzheimer's disease. But new data show that
statins, like all medications, have their
limitations.
Two recently released studies suggest that
statins (such as Simvastatin, Pravastatin,
Lovastatin, Lipitor and Crestor), when prescribed
to lower cholesterol, do not prolong life in
healthy patients at high risk of having a heart
attack or a stroke.
In the first study, published in the Archives
of Internal Medicine, United Kingdom scientists
analyzed mortality rates of more than 65,000
people, half of whom were treated with statins.
All participants were considered at high risk of
heart disease and had elevated cholesterol levels.
Although life expectancy was no different in
either group, the patients taking statins
experienced a 55 percent reduction in the risk of
nonfatal heart attacks and a 45 percent reduction
in nonfatal strokes. In other words, the patients
who took statins did not live any longer, but they
were less likely to be disabled either from a
stroke or heart failure.
Published in the Archives of Internal Medicine,
an even more alarming analysis revealed flaws in a
well-respected study that showed the benefit of
prescribing statins to patients who had an
elevated C-reactive protein (CRP) but normal
cholesterol. The CRP is a marker of inflammation —
when elevated it's known to be a risk factor for
heart attacks and strokes.
This initial study led to a change in practice,
and even more patients were placed on the most
expensive statin (Crestor), which was used in the
study to help reduce heart attack risk.
Researchers from France re-examined the
information and felt that the benefits were
overstated and the outcomes flawed. Because the
maker of Crestor sponsored the study and the lead
author, Dr. Paul Ridker, has a patent on the CRP
test, the French researchers raised serious
concerns that bias may have affected the results.
This new information on statins highlights a
recurring theme in modern medicine — science
always changes and interpreting medical studies
can be confusing. Over time the benefits of any
particular therapy, often thought to be
unequivocal, will become open to question.
Currently, there is a consensus among
physicians that anyone with elevated cholesterol,
particularly an elevation of the bad or LDL
cholesterol, should be treated to reduce the level
to acceptable values. Men and women in their 40s
with no other risk factors for heart disease (such
as high blood pressure, diabetes, strong family
history) are being treated with statins,
contributing significantly to the $26 billion
spent annually on such treatment.
With this new information, however, many
physicians will likely choose to be less liberal
with statin prescriptions. But there is still some
evidence that for those at very high risk of heart
disease, treatment with a statin will reduce the
risk of heart attacks and strokes that are
nonfatal.
If you are a man or postmenopausal woman with
diabetes, hypertension, a history of smoking, a
strong family history of heart disease and an
elevated cholesterol, treatment with a generic
statin is rational. On the other hand, if you have
no risk factors and your cholesterol is only
minimally increased, treatment with a statin may
not be needed.
No matter your risk factor, the solution to a
better and perhaps a longer life will never ever
be improved by drug therapy. The fountain of youth
will never come in pill form. First and foremost,
the key to longevity is a commitment to a lifelong
pursuit of health.
If your cholesterol is minimally elevated, diet
and exercise often will not only lower the value
to normal, but it will improve your blood
pressure, reduce your risk of diabetes and perhaps
even prolong your life. Add to the mix by
maintaining low stress and having a full and
passionate life. By doing all of this, you can
rest assured that the quality of your life will be
better — even if the quantity is unchanged.
Dr. David Lipschitz is the author of the books,
"Breaking the Rules of Aging" and "Dr. David's
First Health Book of More Not Less." To find out
more about Dr. David Lipschitz and read features
by other Creators Syndicate writers and
cartoonists, visit the Creators Syndicate Web page
at www.creators.com. More information is available
at www.DrDavidHealth.com.